How Do Cytokine Receptors Transmit Signals?

The structure of the IL-11 signalling complex provides insight into receptor variants associated with craniosynostosis

DD Sentosa, RD Metcalfe, NA Sims, TL Putoczki, MDW Griffin

2025-02-01

Interleukin 11 (IL-11), a member of the IL-6 family of cytokines, has roles in haematopoiesis, inflammation, bone metabolism, and ..

Craniosynostosis-associated variants in the IL-11R complex: new insights and questions

NA Sims, MDW Griffin

2024-04-01

Skull growth involves the expansion of both the flat calvarial bones of the skull and the fibrous marginal zones, termed sutures, ..

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

RD Metcalfe, E Hanssen, KY Fung, K Aizel, CC Kosasih, CO Zlatic, L Doughty, CJ Morton, AP Leis, MW Parker, PR Gooley, TL Putoczki, MDW Griffin

2023-12-01

Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers...